Contiene: Introduction and definitions of autoinmunity and autoinmmune disease. Introduction to the immune system: focus on autoimmune mechanisms. Intrinsic factors in autoinmmunity. Clinical expression of human autoimmune disease. Epidemiology. Mechanisms of chemical-associated autoimmune responses. Chemical/physical agent and autoimmunity. Non-chemical factors in autoimmunity. Animal models to assess chemical-induced autoimmunity. Human testing for autoimmune disease. Risk assement.