000			02702nab a2200301 a 4500
003			AR-ReUNN
005			20260702004710.0
008			260701s2021 ag |||||||||||||||||eng
041	0		_aeng
100	1		_aOuchi, Kentaro _9197076
245	1	3	_aEl número y tipo de antiepilépticos afectan el requerimiento de dosis de propofol para la anestesia: estudio observacional.
246	1	3	_aThe number and kind of antiepileptics affect propofol dose requirement for anesthesia: observational study
264		1	_c2021
300			_a7 páginas
520			_aThe propofol dose requirement and the emergence time are affected by antiepileptic use. The effects on anesthesia of the number and kind of antiepileptic agents have not been reported. We investigated the relationship between the kind and number of antiepileptic agents and the propofol dose requirement for anesthesia and emergence time in intravenous general anesthesia for dental treatment for patients with neurological disorders. We studied 247 patients with neurological disorders who underwent dental treatment under intravenous general anesthesia. Patients were categorized according to the number of antiepileptics (none, single agent, two kinds, and three or more kinds of antiepileptics) and the kind of antiepileptic (carbamazepine, valproate, phenobarbital, phenytoin, zonisamide, clobazam, or topiramate) being received. The propofol dose requirement for anesthesia, emergence time, and predicted blood propofol concentration at emergence were evaluated. Patients on three or more kinds of antiepileptics had significantly lower propofol dose requirement (reduction in 25%, compare with no use) and predicted blood propofol concentration at emergence (reduction in 41%) and significantly longer emergence time (extension in 50%) (P?<?0.05). Valproate and clobazam reduced the propofol dose (valproate 9% and clobazam 19%) and predicted blood propofol concentration at emergence (valproate 18% and clobazam 33%), while phenobarbital increased these parameters (30% and 125%) (P?<?0.05). The number and kind of antiepileptics effects propofol dose requirement. In particular, valproate and clobazam reduce the propofol dose requirement, while phenobarbital increases this.
650		4	_aAnestesicos _9117356
650		4	_aDesorden Neurològico _9197077
650		4	_aTratamiento Dental _9184688
650		4	_aAnestesia General Intravenosa _9197078
650		4	_aMedula Suprarrenal _9197079
650		4	_aAntiepilecticos _9197080
650		4	_aPropofol _9197081
650		4	_aDosis de Propofol _9197082
773	0		_tOdontology _x1618-1247 _gv. 108 n. 1 (2020) _w257190
942			_cART
035			_a(ODN)64335
001			265457
999			_c265457 _d265457
040			_aAR-ReUNN _bspa _cAR-ReUNN _eaacr2