| 000 | 02722nab a2200349 a 4500 | ||
|---|---|---|---|
| 003 | AR-ReUNN | ||
| 005 | 20260702004710.0 | ||
| 008 | 260701s2021 ag |||||||||||||||||eng | ||
| 041 | 0 | _aeng | |
| 100 | 1 |
_aIto, Yuki _9197031 |
|
| 700 | 1 |
_aIto, Takashi _9197032 |
|
| 700 | 1 |
_aYamashiro, Keisuke _9197033 |
|
| 700 | 1 |
_aMineshiba, Fumi _9197034 |
|
| 700 | 1 |
_aHirai, Kimito _9197035 |
|
| 700 | 1 |
_aOmori, Kazuhiro _9197036 |
|
| 700 | 1 |
_aYamamoto, Tadashi _9197037 |
|
| 700 | 1 |
_aTakashiba, Shogo _9195807 |
|
| 245 | 1 | 0 | _aEfectos antimicrobianos y antibiofilm del ácido abiético sobre Streptococcus mutans cariogénico |
| 246 | 1 | 3 | _aAntimicrobial and antibiofilm effects of abietic acid on cariogenic streptococcus mutans |
| 264 | 1 | _c2021 | |
| 300 | _a9 páginas | ||
| 520 | _aDental caries is a type of oral microbiome dysbiosis and biofilm infection that affects oral and systemic conditions. For healthy life expectancy, natural bacteriostatic products are ideal for daily and lifetime use as anti-oral infection agents. This study aimed to evaluate the inhibitory effects of abietic acid, a diterpene derived from pine rosin, on the in vitro growth of cariogenic bacterial species, Streptococcus mutans. The effective minimum inhibitory concentration of abietic acid was determined through observation of S. mutans growth, acidification, and biofilm formation. The inhibitory effects of abietic acid on the bacterial membrane were investigated through the use of in situ viability analysis and scanning electron microscopic analysis. Cytotoxicity of abietic acid was also examined in the context of several human cell lines using tetrazolium reduction assay. Abietic acid was found to inhibit key bacterial growth hallmarks such as colony forming ability, adenosine triphosphate activity (both planktonic and biofilm), acid production, and biofilm formation. Abietic acid was identified as bacteriostatic, and this compound caused minimal damage to the bacterial membrane. This action was different from that of povidone-iodine or cetylpyridinium chloride. Additionally, abietic acid was significantly less cytotoxic compared to povidone-iodine, and it exerted lower toxicity towards epithelial cells and fibroblasts compared to that against monocytic cells. These data suggest that abietic acid may prove useful as an antibacterial and antibiofilm agent for controlling S. mutans infection. | ||
| 650 | 4 |
_aAcido Abietico _9197038 |
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| 650 | 4 |
_aStreptococcus Mutans _910290 |
|
| 650 | 4 |
_aAntimicrobiano _9195431 |
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| 650 | 4 |
_aBiofilm Oral _9197039 |
|
| 650 | 4 |
_aTerpenos _9197040 |
|
| 773 | 0 |
_tOdontology _x1618-1247 _gv. 108 n. 1 (2020) _w257190 |
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| 942 | _cART | ||
| 035 | _a(ODN)64309 | ||
| 001 | 265441 | ||
| 999 |
_c265441 _d265441 |
||
| 040 |
_aAR-ReUNN _bspa _cAR-ReUNN _eaacr2 |
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