000			02057nab a2200313 a 4500
003			AR-ReUNN
005			20260702004709.0
008			260701s2021 ag |||||||||||||||||eng
041	0		_aeng
100	1		_aOka, Shunya _9196999
700	1		_aOkabe, Miku _9197000
700	1		_aTsubura, Schuici _9197001
700	1		_aMikami, Masato _9197002
700	1		_aImai, Akane _9197003
245	1	0	_aPropiedades de los fucoidanos beneficiosos para la salud bucal
246	1	3	_aProperties of fucoidans beneficial to oral healthcare
264		1	_c2021
300			_a9 páginas
520			_aFucoidans are sulfated polysaccharides that are found in marine algae and have many useful activities, including antitumor effects, promotion of apoptosis of cancer cells, and antiviral, anti-inflammatory, and antiallergic actions. In oral medicine, several case reports have shown that fucoidan-containing creams and tablets markedly improved recurrent aphthous stomatitis, symptomatic inflamed tongue, and recurrent oral herpes labialis. The aim of this study was to examine the properties of fucoidans for use in oral healthcare. The antimicrobial, anti-adhesion, endotoxin-neutralizing, and cyclooxygenase (COX)-1 and COX-2 inhibitory activities of fucoidans were examined. Four key results were obtained: fucoidans showed strong antimicrobial activity against Candida albicans, Streptococcus mutans, and Porphyromonas gingivalis; significantly inhibited the adhesion of S. mutans to bovine teeth and porcelain; were suggested to bind to and neutralize endotoxin (lipopolysaccharide) in an LAL assay; and showed COX-1 and/or COX-2 inhibitory activity. These results suggested that fucoidans may be useful in the field of oral healthcare.
650		4	_aFucoidan _9197004
650		4	_aAntimicrobiano _9195431
650		4	_aNeutralizacion de Endotoxinas _9197005
650		4	_aAntiinflamatorios _9117861
650		4	_aSalud Bucal _94920
773	0		_tOdontology _x1618-1247 _gv. 108 n. 1 (2020) _w257190
942			_cART
035			_a(ODN)64304
001			265437
999			_c265437 _d265437
040			_aAR-ReUNN _bspa _cAR-ReUNN _eaacr2