| 000 | 02971nab a2200433 a 4500 | ||
|---|---|---|---|
| 003 | AR-ReUNN | ||
| 005 | 20260702004709.0 | ||
| 008 | 260701s2021 ag |||||||||||||||||eng | ||
| 041 | 0 | _aeng | |
| 100 | 1 |
_aToraya, Seiko _9196979 |
|
| 700 | 1 |
_aUehara, Osamu _9196980 |
|
| 700 | 1 |
_aHiraki, Daichi _9196981 |
|
| 700 | 1 |
_aHarada, Fumiya _9196982 |
|
| 700 | 1 |
_aNeopane, Puja _9196983 |
|
| 700 | 1 |
_aMorikawa, Tetsuro _9196984 |
|
| 700 | 1 |
_aTakai, Rie _9196985 |
|
| 700 | 1 |
_aYoshida, Koki _9196986 |
|
| 700 | 1 |
_aMatsuoka, Hirofumi _9196987 |
|
| 700 | 1 |
_aKitaichi, Nobuyoshi _9196988 |
|
| 700 | 1 |
_aChiba, Itsuo _9196989 |
|
| 700 | 1 |
_aAbiko, Yoshihiro _9196990 |
|
| 245 | 1 | 3 | _aLa curcumina inhibe la expresión de mediadores proinflamatorios y MMP-9 en células epiteliales gingivales estimuladas durante un período prolongado con lipopolisacáridos derivados de Porphyromonas gingivalis |
| 246 | 1 | 3 | _aCurcumin inhibits the expression of proinflammatory mediators and mmp-9 in gingival epithelial cells stimulated for a proloned period whit lipopolysaccharides derived from porphyromonas gingivalis |
| 264 | 1 | _c2021 | |
| 300 | _a9 páginas | ||
| 520 | _aCurcumin, a yellow phytochemical found in the rhizomes of Curcuma longa, has various biological effects, including anti-oxidant and anti-inflammatory activities. In the present study, we examined the effect of curcumin on the expression of inflammatory cytokines in human gingival epithelial progenitor cells (HGEPs) stimulated for a prolonged period with lipopolysaccharide (LPS) derived from Porphyromonas gingivalis. The cells were alternately cultured with LPS and/or curcumin every 3 days for 18 days. The expression levels of TNF-a, IL-1ß, IL-6, TIMP-1, and MMP-9 in the HGEPs were evaluated by quantitative real-time polymerase chain reaction. Enzyme-linked immunosorbent assay was used to measure the concentrations of these five proteins in the supernatant and nuclear factor (NF)-?B in the nuclear extracts. Curcumin inhibited the mRNA expression levels of TNF-a, IL-1ß, IL-6, and MMP-9 in HGEPs treated with curcumin over a prolonged period. Similarly, the expression levels of IL-1ß, IL-6, and MMP-9 were decreased in the culture supernatants. NF-?B activity was also inhibited in the cells cultured with curcumin. In conclusion, these findings indicate that curcumin inhibits the expression of inflammatory cytokines and MMP-9 in primary gingival epithelial cells stimulated with P. gingivalis-derived LPS via NF-?B activation. | ||
| 650 | 4 |
_aFracturas Complicadas _9168255 |
|
| 650 | 4 |
_aLipopolisacaridos _9144642 |
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| 650 | 4 |
_aCurcumina _9196991 |
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| 650 | 4 |
_aCelulas Epiteliales _9124034 |
|
| 650 | 4 |
_aPatología Bucomaxilofacial _9190780 |
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| 650 | 4 |
_aInhibición _915880 |
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| 650 | 4 |
_aMediadores Proinflamatorios _9174273 |
|
| 650 | 4 |
_aEstimulación _95122 |
|
| 773 | 0 |
_tOdontology _x1618-1247 _gv. 108 n. 1 (2020) _w257190 |
|
| 942 | _cART | ||
| 035 | _a(ODN)64302 | ||
| 001 | 265435 | ||
| 999 |
_c265435 _d265435 |
||
| 040 |
_aAR-ReUNN _bspa _cAR-ReUNN _eaacr2 |
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