000			02773nab a2200277 a 4500
003			AR-ReUNN
005			20260702004709.0
008			260701s2021 ag |||||||||||||||||eng
041	0		_aeng
100	1		_aOrnoy, Asher _9196973
245	1	0	_aMalformaciones craneofaciales y su asociación con el desarrollo cerebral: la importancia de un enfoque multidisciplinario para el tratamiento
246	1	3	_aCraniofacial malformations and their association with brain development: the importance of a multidisciplinary approach for treatment
264		1	_c2021
300			_a15 páginas
520			_aThe craniofacial complex develops mainly in the first trimester of pregnancy, but its final shaping and the development of the teeth extend into the second and third trimesters. It is intimately connected with the development of the brain because of the crucial role the cranial neural crest cells play and the fact that many signals which control craniofacial development originate in the brain and vice versa. As a result, malformations of one organ may affect the development of the other. Similarly, there are developmental connections between the craniofacial complex and the teeth. Craniofacial anomalies are either isolated, resulting from abnormal development of the first two embryonic pharyngeal arches, or part of multiple malformation syndromes affecting many other organs. They may stem from gene mutations, chromosomal aberrations or from environmental causes induced by teratogens. The craniofacial morphologic changes are generally cosmetic, but they often interfere with important functions such as chewing, swallowing and respiration. In addition, they may cause hearing or visual impairment. In this review we discussed only a small number of craniofacial malformations and barely touched upon related anomalies of dentition. Following a brief description of the craniofacial development, we discussed oral clefts, craniofacial microsomia, teratogens that may interfere with craniofacial development resulting in different malformations, the genetically determined craniosynostoses syndromes and few other relatively common syndromes that, in addition to the craniofacial complex, also affect other organs. The understanding of these malformations is important in dentistry as dentists play an integral role in their diagnosis and multidisciplinary treatment.
650		4	_aMalformaciones Craneofaciales _9168213
650		4	_aDesarrollo Cerebral _9196974
650		4	_aMicrosomia _9196975
650		4	_aHendiduras Orales _9196976
650		4	_aCraniosinostosis _9196977
650		4	_aDiagnostico Multidisciplinario _9196978
773	0		_tOdontology _x1618-1247 _gv. 108 n. 1 (2020) _w257190
942			_cART
035			_a(ODN)64301
001			265434
999			_c265434 _d265434
040			_aAR-ReUNN _bspa _cAR-ReUNN _eaacr2