| 000 | 01825nab a2200337 a 4500 | ||
|---|---|---|---|
| 003 | AR-ReUNN | ||
| 005 | 20260702002328.0 | ||
| 008 | 260630s1985 gw |||||||||||||||||eng | ||
| 041 | 0 | _aeng | |
| 100 | 1 |
_aHuxtable, Clive R. R. _9126840 |
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| 700 | 1 |
_aDorling, P. R. _9126841 |
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| 245 | 1 | 0 | _aMannoside storage and axonal dystrophy in sensory neurones of swainsonine-treated rats: Morphogenesis of lesions / C. R. Huxtable; P. R. Dorling |
| 264 | 1 |
_aBerlin _bSpringer _c1985 |
|
| 300 | _a9 páginas | ||
| 500 | _aDisponible en http://www.springerlink.com/content/t9240715627620j1/ | ||
| 520 | _aSummary Young rats were treated with swainsonine for up to 200 days at a dose rate that restricted neuronal mannoside storage to neurones not protected by the blood/brain barrier. In lumbar dorsal root ganglion neurones, mannoside storage in the cell body developed in parallel to dystrophic changes at the extremities of peripherally and centrally directed axons. The dystrophic process involved the accumulation of autophagic structures. In the CNS, axonal dystrophy was confined to areas receiving long processes from affected neurones. The results suggest that axonal dystrophy is a direct consequence of the lysosomal storage process in parent cell bodies. The possible relationship of axonal dystrophy to neuronal lysosomal function is discussed. | ||
| 650 | 4 |
_aRata _9117553 |
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| 650 | 4 |
_aNeuronas _9125042 |
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| 650 | 4 |
_aDistrofia _9126842 |
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| 650 | 4 |
_aMorfogenesis _99254 |
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| 650 | 4 |
_aLesiones _910073 |
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| 650 | 4 |
_aMusculos _938670 |
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| 650 | 4 |
_aMorfología Animal _962048 |
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| 650 | 4 |
_aRoedores _94076 |
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| 650 | 4 |
_aExperimentación _911630 |
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| 650 | 4 |
_aSeparatas _9120950 |
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| 773 | 0 |
_tActa Neuropathol _x0001-6322 _gv. 68 n. 1 (1985) _w223998 |
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| 942 | _cART | ||
| 035 | _a(AGROP)45835 | ||
| 001 | 218766 | ||
| 999 |
_c218766 _d218766 |
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| 040 |
_aAR-ReUNN _bspa _cAR-ReUNN _eaacr2 |
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