02702nab a2200301 a 4500 AR-ReUNN 20260702004710.0 260701s2021 ag |||||||||||||||||eng eng Ouchi, Kentaro 197076 El número y tipo de antiepilépticos afectan el requerimiento de dosis de propofol para la anestesia: estudio observacional. The number and kind of antiepileptics affect propofol dose requirement for anesthesia: observational study 2021 7 páginas The propofol dose requirement and the emergence time are affected by antiepileptic use. The effects on anesthesia of the number and kind of antiepileptic agents have not been reported. We investigated the relationship between the kind and number of antiepileptic agents and the propofol dose requirement for anesthesia and emergence time in intravenous general anesthesia for dental treatment for patients with neurological disorders. We studied 247 patients with neurological disorders who underwent dental treatment under intravenous general anesthesia. Patients were categorized according to the number of antiepileptics (none, single agent, two kinds, and three or more kinds of antiepileptics) and the kind of antiepileptic (carbamazepine, valproate, phenobarbital, phenytoin, zonisamide, clobazam, or topiramate) being received. The propofol dose requirement for anesthesia, emergence time, and predicted blood propofol concentration at emergence were evaluated. Patients on three or more kinds of antiepileptics had significantly lower propofol dose requirement (reduction in 25%, compare with no use) and predicted blood propofol concentration at emergence (reduction in 41%) and significantly longer emergence time (extension in 50%) (P?<?0.05). Valproate and clobazam reduced the propofol dose (valproate 9% and clobazam 19%) and predicted blood propofol concentration at emergence (valproate 18% and clobazam 33%), while phenobarbital increased these parameters (30% and 125%) (P?<?0.05). The number and kind of antiepileptics effects propofol dose requirement. In particular, valproate and clobazam reduce the propofol dose requirement, while phenobarbital increases this. Anestesicos 117356 Desorden Neurològico 197077 Tratamiento Dental 184688 Anestesia General Intravenosa 197078 Medula Suprarrenal 197079 Antiepilecticos 197080 Propofol 197081 Dosis de Propofol 197082 Odontology 1618-1247 v. 108 n. 1 (2020) 257190 ART (ODN)64335 265457 265457 265457 AR-ReUNN spa AR-ReUNN aacr2