02105nab a2200325 a 4500003000900000005001700009008004100026041000800067100002400075700002400099700002900123700002700152700002400179245006700203246005800270264000900328300001600337520114600353650002101499650002701520650004201547650003001589650002201619773005401641942000801695035001501703001000701718999001901725040003501744AR-ReUNN20260702004709.0260701s2021    ag |||||||||||||||||eng  0 aeng1 aOka, Shunya91969991 aOkabe, Miku91970001 aTsubura, Schuici91970011 aMikami, Masato91970021 aImai, Akane919700310aPropiedades de los fucoidanos beneficiosos para la salud bucal13aProperties of fucoidans beneficial to oral healthcare 1c2021  a9 páginas  aFucoidans are sulfated polysaccharides that are found in marine algae and have many useful activities, including antitumor effects, promotion of apoptosis of cancer cells, and antiviral, anti-inflammatory, and antiallergic actions. In oral medicine, several case reports have shown that fucoidan-containing creams and tablets markedly improved recurrent aphthous stomatitis, symptomatic inflamed tongue, and recurrent oral herpes labialis. The aim of this study was to examine the properties of fucoidans for use in oral healthcare. The antimicrobial, anti-adhesion, endotoxin-neutralizing, and cyclooxygenase (COX)-1 and COX-2 inhibitory activities of fucoidans were examined. Four key results were obtained: fucoidans showed strong antimicrobial activity against Candida albicans, Streptococcus mutans, and Porphyromonas gingivalis; significantly inhibited the adhesion of S. mutans to bovine teeth and porcelain; were suggested to bind to and neutralize endotoxin (lipopolysaccharide) in an LAL assay; and showed COX-1 and/or COX-2 inhibitory activity. These results suggested that fucoidans may be useful in the field of oral healthcare. 4aFucoidan9197004 4aAntimicrobiano9195431 4aNeutralizacion de Endotoxinas9197005 4aAntiinflamatorios9117861 4aSalud Bucal949200 tOdontologyx1618-1247gv. 108 n. 1 (2020)w257190  cART  a(ODN)64304265437  c265437d265437  aAR-ReUNNbspacAR-ReUNNeaacr2