02057nab a2200313 a 4500 AR-ReUNN 20260702004709.0 260701s2021 ag |||||||||||||||||eng eng Oka, Shunya 196999 Okabe, Miku 197000 Tsubura, Schuici 197001 Mikami, Masato 197002 Imai, Akane 197003 Propiedades de los fucoidanos beneficiosos para la salud bucal Properties of fucoidans beneficial to oral healthcare 2021 9 páginas Fucoidans are sulfated polysaccharides that are found in marine algae and have many useful activities, including antitumor effects, promotion of apoptosis of cancer cells, and antiviral, anti-inflammatory, and antiallergic actions. In oral medicine, several case reports have shown that fucoidan-containing creams and tablets markedly improved recurrent aphthous stomatitis, symptomatic inflamed tongue, and recurrent oral herpes labialis. The aim of this study was to examine the properties of fucoidans for use in oral healthcare. The antimicrobial, anti-adhesion, endotoxin-neutralizing, and cyclooxygenase (COX)-1 and COX-2 inhibitory activities of fucoidans were examined. Four key results were obtained: fucoidans showed strong antimicrobial activity against Candida albicans, Streptococcus mutans, and Porphyromonas gingivalis; significantly inhibited the adhesion of S. mutans to bovine teeth and porcelain; were suggested to bind to and neutralize endotoxin (lipopolysaccharide) in an LAL assay; and showed COX-1 and/or COX-2 inhibitory activity. These results suggested that fucoidans may be useful in the field of oral healthcare. Fucoidan 197004 Antimicrobiano 195431 Neutralizacion de Endotoxinas 197005 Antiinflamatorios 117861 Salud Bucal 4920 Odontology 1618-1247 v. 108 n. 1 (2020) 257190 ART (ODN)64304 265437 265437 265437 AR-ReUNN spa AR-ReUNN aacr2