01976nab a2200301 a 4500003000900000005001700009008004100026041000800067100001600075700001600091700002100107700001900128700001600147245006700163246005800230264000900288300001600297520114600313650001301459650001901472650003401491650002201525650001601547773005401563035001501617001000701632040003501639AR-ReUNN20260702004709.0260701s2021    ag |||||||||||||||||eng  0 aeng1 aOka, Shunya1 aOkabe, Miku1 aTsubura, Schuici1 aMikami, Masato1 aImai, Akane10aPropiedades de los fucoidanos beneficiosos para la salud bucal13aProperties of fucoidans beneficial to oral healthcare 1c2021  a9 páginas  aFucoidans are sulfated polysaccharides that are found in marine algae and have many useful activities, including antitumor effects, promotion of apoptosis of cancer cells, and antiviral, anti-inflammatory, and antiallergic actions. In oral medicine, several case reports have shown that fucoidan-containing creams and tablets markedly improved recurrent aphthous stomatitis, symptomatic inflamed tongue, and recurrent oral herpes labialis. The aim of this study was to examine the properties of fucoidans for use in oral healthcare. The antimicrobial, anti-adhesion, endotoxin-neutralizing, and cyclooxygenase (COX)-1 and COX-2 inhibitory activities of fucoidans were examined. Four key results were obtained: fucoidans showed strong antimicrobial activity against Candida albicans, Streptococcus mutans, and Porphyromonas gingivalis; significantly inhibited the adhesion of S. mutans to bovine teeth and porcelain; were suggested to bind to and neutralize endotoxin (lipopolysaccharide) in an LAL assay; and showed COX-1 and/or COX-2 inhibitory activity. These results suggested that fucoidans may be useful in the field of oral healthcare. 4aFucoidan 4aAntimicrobiano 4aNeutralizacion de Endotoxinas 4aAntiinflamatorios 4aSalud Bucal0 tOdontologyx1618-1247gv. 108 n. 1 (2020)w257190  a(ODN)64304265437  aAR-ReUNNbspacAR-ReUNNeaacr2