02290nab a2200289 a 4500 AR-ReUNN 20260702003057.0 260630s2006 ag |||||||||||||||||eng eng Morgan, Marjorie S. 147550 Moore, Peter F. 147551 Stemmer, Betty L. 147552 Rapp, Christine M. 147553 Arlian, Larry G. 147554 Characterization of lymphocyte subtypes in scabietic skin lesions of naive and sensitized dogs / Larry G. Arlian ...[et al.]. 2006 12 páginas Disponible en caja 26 no 8 de INICNE We delineated the density of cells expressing CD4, CD8, CD21 and CD45RA antigens in the cellular infiltrates in the epidermis, dermis and follicular epithelium in scabietic skin lesions of naive hosts and sensitized hosts that expressed resistance to scabies infestation. No cells expressing CD21 (B- lymphocytes and follicular dendritic cells) were present in the epidermis and only a few were occasionally present in the dermis during both the first and second infestations. Naive T-cells (CD45RA +) and CD8 + cells (cytotoxic and suppressor T- lymphocytes) were present in varying densities in the infiltrates throughout the epidermis, dermis and follicular epithelium with no apparent differences in density and the rate of appearance between sensitizing and challenge infestations. CD4 + cells were abundant in fluctuating densities in the dermis, epidermis, and follicular epidermis during the sensitizing infestation and these cells became the dominant cell type early during the challenge infestation. The density of CD4 + cells in the infiltrate was much greater during the challenge than during the sensitization infestation. This population of CD4 + cells consisted of both T-helper/inducer cells and neutrophils and the large increase in their numbers during the challenge suggested they played a key role in the successful immune/inflammatory response that resulted in resistance to scabies infestation. Perro 10161 Lesiones 10073 Riñones 119681 Veterinary Parasitology v. 4 (68) 234688 ART (INICN)35977 234689 234689 234689 AR-ReUNN spa AR-ReUNN aacr2