Huxtable, Clive R. R. creator Dorling, P. R. text gw 1985 continuing eng 9 páginas Summary Young rats were treated with swainsonine for up to 200 days at a dose rate that restricted neuronal mannoside storage to neurones not protected by the blood/brain barrier. In lumbar dorsal root ganglion neurones, mannoside storage in the cell body developed in parallel to dystrophic changes at the extremities of peripherally and centrally directed axons. The dystrophic process involved the accumulation of autophagic structures. In the CNS, axonal dystrophy was confined to areas receiving long processes from affected neurones. The results suggest that axonal dystrophy is a direct consequence of the lysosomal storage process in parent cell bodies. The possible relationship of axonal dystrophy to neuronal lysosomal function is discussed. Disponible en http://www.springerlink.com/content/t9240715627620j1/ Rata Neuronas Distrofia Morfogenesis Lesiones Musculos Morfología Animal Roedores Experimentación Separatas 0001-6322 223998 v. 68 n. 1 (1985) AR-ReUNN 260630 20260702002328.0 218766 spa