01825nab a2200337 a 4500 AR-ReUNN 20260702002328.0 260630s1985 gw |||||||||||||||||eng eng Huxtable, Clive R. R. 126840 Dorling, P. R. 126841 Mannoside storage and axonal dystrophy in sensory neurones of swainsonine-treated rats: Morphogenesis of lesions / C. R. Huxtable; P. R. Dorling Berlin Springer 1985 9 páginas Disponible en http://www.springerlink.com/content/t9240715627620j1/ Summary Young rats were treated with swainsonine for up to 200 days at a dose rate that restricted neuronal mannoside storage to neurones not protected by the blood/brain barrier. In lumbar dorsal root ganglion neurones, mannoside storage in the cell body developed in parallel to dystrophic changes at the extremities of peripherally and centrally directed axons. The dystrophic process involved the accumulation of autophagic structures. In the CNS, axonal dystrophy was confined to areas receiving long processes from affected neurones. The results suggest that axonal dystrophy is a direct consequence of the lysosomal storage process in parent cell bodies. The possible relationship of axonal dystrophy to neuronal lysosomal function is discussed. Rata 117553 Neuronas 125042 Distrofia 126842 Morfogenesis 9254 Lesiones 10073 Musculos 38670 Morfología Animal 62048 Roedores 4076 Experimentación 11630 Separatas 120950 Acta Neuropathol 0001-6322 v. 68 n. 1 (1985) 223998 ART (AGROP)45835 218766 218766 218766 AR-ReUNN spa AR-ReUNN aacr2